Glucolipotoxicity in Pancreatic β-Cells
نویسندگان
چکیده
منابع مشابه
Glucolipotoxicity in Pancreatic β-Cells
The recent epidemic of type 2 diabetes in Asia differs from that reported in other regions of the world in several key areas: it has evolved over a much shorter time, in an earlier stage of life, and in people with lower body mass indices. These phenotypic characteristics of patients strongly suggest that insulin secretory defects may perform a more important function in the development and pro...
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The glucolipotoxicity hypothesis postulates that chronically elevated levels of glucose and fatty acids adversely affect pancreatic β-cell function and thereby contribute to the deterioration of insulin secretion in Type 2 diabetes. Whereas ample experimental evidence in in vitro systems supports the glucolipotoxicity hypothesis, the contribution of this phenomenon to β-cell dysfunction in huma...
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ژورنال
عنوان ژورنال: Diabetes & Metabolism Journal
سال: 2011
ISSN: 2233-6079
DOI: 10.4093/dmj.2011.35.5.444